Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

by Elisabet Ihse, Hodaka Yamakado, Xander M. van Wijk, Roger Lawrence, Jeffrey D. Esko, Eliezer Masliah
Published 2017-08-01

Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems.

by Yung-Chi Chang, Zhipeng Wang, Lindsay A Flax, Ding Xu, Jeffrey D Esko, Victor Nizet, Miriam J Baron
Published 2011-06-01

Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice.

by Brett E Crawford, Omai B Garner, Joseph R Bishop, David Y Zhang, Kevin T Bush, Sanjay K Nigam, Jeffrey D Esko
Published 2010-05-01

Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I.

by Omar Khalid, Moin U Vera, Philip L Gordts, N Matthew Ellinwood, Philip H Schwartz, Patricia I Dickson, Jeffrey D Esko, Raymond Y Wang
Published 2016-01-01

Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis

by Alejandro Gómez Toledo, Gregory Golden, Alexandre Rosa Campos, Hector Cuello, James Sorrentino, Nathan Lewis, Nissi Varki, Victor Nizet, Jeffrey W. Smith, Jeffrey D. Esko
Published 2019-10-01

Correction to: Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy

by Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko, Nadia Soussi-Yanicostas
Published 2020-12-01

Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy

by Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko, Nadia Soussi-Yanicostas
Published 2018-03-01

Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease

by Julia A. Callender, Alejandro M. Sevillano, Katrin Soldau, Timothy D. Kurt, Taylor Schumann, Donald P. Pizzo, Hermann Altmeppen, Markus Glatzel, Jeffrey D. Esko, Christina J. Sigurdson
Published 2020-08-01

Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans.

by Joseph R Bishop, Maria Rita Passos-Bueno, Loren Fong, Kristin I Stanford, Jon C Gonzales, Erika Yeh, Stephen G Young, Andre Bensadoun, Joseph L Witztum, Jeffrey D Esko, Karen S Moulton
Published 2010-11-01

Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection.

by Erbin Dai, Li-Ying Liu, Hao Wang, Dana McIvor, Yun Ming Sun, Colin Macaulay, Elaine King, Ganesh Munuswamy-Ramanujam, Mee Yong Bartee, Jennifer Williams, Jennifer Davids, Israel Charo, Grant McFadden, Jeffrey D Esko, Alexandra R Lucas
Published 2010-05-01

Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume.

by Sophie J Bernelot Moens, Hans L Mooij, H Carlijne Hassing, Janine K Kruit, Julia J Witjes, Michiel A J van de Sande, Aart J Nederveen, Ding Xu, Geesje M Dallinga-Thie, Jeffrey D Esko, Erik S G Stroes, Max Nieuwdorp
Published 2014-01-01

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

by Bastian Ramms, Sohan Patel, Chelsea Nora, Ariane R. Pessentheiner, Max W. Chang, Courtney R. Green, Gregory J. Golden, Patrick Secrest, Ronald M. Krauss, Christian M. Metallo, Christopher Benner, Veronica J. Alexander, Joseph L. Witztum, Sotirios Tsimikas, Jeffrey D. Esko, Philip L.S.M. Gordts
Published 2019-08-01

A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia

by Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S. Koechlein, Nikki Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H. Ginsberg, Pyong Woo Park, Jeffrey D. Esko, Tannishtha Reya
Published 2020-11-01

Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion

by Xander M. van Wijk, Simon Dohrmann, Bjorn M. Hallstrom, Shangzhong Li, Bjørn G. Voldborg, Brandon X. Meng, Karen K. McKee, Toin H. van Kuppevelt, Peter D. Yurchenco, Bernhard O. Palsson, Nathan E. Lewis, Victor Nizet, Jeffrey D. Esko, Pyong Park, Gerald B. Pier
Published 2017-01-01

Oncofetal Chondroitin Sulfate Is a Highly Expressed Therapeutic Target in Non-Small Cell Lung Cancer

by Htoo Zarni Oo, Zoltan Lohinai, Nastaran Khazamipour, Joey Lo, Gunjan Kumar, Jessica Pihl, Hans Adomat, Noushin Nabavi, Hakhamanesh Behmanesh, Beibei Zhai, Robert Dagil, Swati Choudhary, Tobias Gustavsson, Thomas M. Clausen, Jeffrey D. Esko, Jeffrey W. Allen, Michael A. Thompson, Nhan L. Tran, Judit Moldvay, Balazs Dome, Ali Salanti, Nader Al-Nakouzi, Glen J. Weiss, Mads Daugaard
Published 2021-09-01