Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

by Shao H. Yang, Sandy Y. Chang, Douglas A. Andres, H. Peter Spielmann, Stephen G. Young, Loren G. Fong
Published 2010-02-01

Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL[S]

by Mikael Larsson, Christopher M. Allan, Rachel S. Jung, Patrick J. Heizer, Anne P. Beigneux, Stephen G. Young, Loren G. Fong
Published 2017-09-01

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

by Kristian Kølby Kristensen, Kristian Kølby Kristensen, Katrine Zinck Leth-Espensen, Katrine Zinck Leth-Espensen, Anni Kumari, Anni Kumari, Anne Louise Grønnemose, Anne Louise Grønnemose, Anne-Marie Lund-Winther, Anne-Marie Lund-Winther, Stephen G. Young, Stephen G. Young, Michael Ploug, Michael Ploug
Published 2021-07-01

Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid

by Paul P. Van Veldhoven, Evelyn de Schryver, Stephen G. Young, An Zwijsen, Marc Fransen, Marc Espeel, Myriam Baes, Elke Van Ael
Published 2020-03-01

Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases[S]

by Shao H. Yang, Sandy Y. Chang, Yiping Tu, Gregory W. Lawson, Martin O. Bergo, Loren G. Fong, Stephen G. Young
Published 2012-01-01

Mobility of “HSPG-bound” LPL explains how LPL is able to reach GPIHBP1 on capillaries

by Christopher M. Allan, Mikael Larsson, Rachel S. Jung, Michael Ploug, André Bensadoun, Anne P. Beigneux, Loren G. Fong, Stephen G. Young
Published 2017-01-01

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression[S]

by Laurent Vergnes, Robert G. Chin, Thomas de Aguiar Vallim, Loren G. Fong, Timothy F. Osborne, Stephen G. Young, Karen Reue
Published 2016-03-01

Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation

by Crystal M. Gigante, Michele Dibattista, Frederick N. Dong, Xiaobin Zheng, Sibiao Yue, Stephen G. Young, Johannes Reisert, Yixian Zheng, Haiqing Zhao
Published 2017-04-01

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

by Simon Mysling, Kristian Kølby Kristensen, Mikael Larsson, Oleg Kovrov, André Bensadouen, Thomas JD Jørgensen, Gunilla Olivecrona, Stephen G Young, Michael Ploug
Published 2016-12-01

Evolution and Medical Significance of LU Domain−Containing Proteins

by Julie Maja Leth, Katrine Zinck Leth-Espensen, Kristian Kølby Kristensen, Anni Kumari, Anne-Marie Lund Winther, Stephen G. Young, Michael Ploug
Published 2019-06-01

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

by Xin Rong, Bo Wang, Merlow M Dunham, Per Niklas Hedde, Jinny S Wong, Enrico Gratton, Stephen G Young, David A Ford, Peter Tontonoz
Published 2015-03-01

Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase

by Anne P. Beigneux, Peter Gin, Brandon S.J. Davies, Michael M. Weinstein, André Bensadoun, Robert O. Ryan, Loren G. Fong, Stephen G. Young
Published 2008-06-01

Immunochemical evidence that human apoB differs when expressed in rodent versus human cells

by Xingyu Wang, Vinita Chauhan, Anh T. Nguyen, Joshua Schultz, Jean Davignon, Stephen G. Young, Jan Borén, Thomas L. Innerarity, Hui Rutai, Ross W. Milne
Published 2003-03-01

High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis[S]

by Haibo Jiang, Chris N. Goulbourne, Angelica Tatar, Kirsten Turlo, Daniel Wu, Anne P. Beigneux, Chris R.M. Grovenor, Loren G. Fong, Stephen G. Young
Published 2014-10-01

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

by Simon Mysling, Kristian Kølby Kristensen, Mikael Larsson, Anne P Beigneux, Henrik Gårdsvoll, Loren G Fong, André Bensadouen, Thomas JD Jørgensen, Stephen G Young, Michael Ploug
Published 2016-01-01

GPIHBP1, an endothelial cell transporter for lipoprotein lipase

by Stephen G. Young, Brandon S.J. Davies, Constance V. Voss, Peter Gin, Michael M. Weinstein, Peter Tontonoz, Karen Reue, André Bensadoun, Loren G. Fong, Anne P. Beigneux
Published 2011-11-01

Agpat6—a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium

by Anne P. Beigneux, Laurent Vergnes, Xin Qiao, Steven Quatela, Ryan Davis, Steven M. Watkins, Rosalind A. Coleman, Rosemary L. Walzem, Mark Philips, Karen Reue, Stephen G. Young
Published 2006-04-01

Generation of monoclonal antibodies specific for mouse apolipoprotein B-100 in apolipoprotein B-48-only mice

by Constance H. Zlot, Laura M. Flynn, Murielle M. Véniant, Edward Kim, Martin Raabe, Sally P.A. McCormick, Patricia Ambroziak, Leslie M. McEvoy, Stephen G. Young
Published 1999-01-01

Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure

by Mikael Larsson, Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Rosemary L. Walzem, Anne P. Beigneux, Stephen G. Young, Loren G. Fong
Published 2018-04-01

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

by Kaori Minehira, Stephen G. Young, Claudio J. Villanueva, Laxman Yetukuri, Matej Oresic, Mark K. Hellerstein, Robert V. Farese, Jr., Jay D. Horton, Frederic Preitner, Bernard Thorens, Luc Tappy
Published 2008-09-01