Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy

by Alexander A Warkentin, Michael S Lopez, Elisabeth A Lasater, Kimberly Lin, Bai-Liang He, Anskar YH Leung, Catherine C Smith, Neil P Shah, Kevan M Shokat
Published 2014-12-01

Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1

by Jesper Pallesen, Yaser Hashem, Gürkan Korkmaz, Ravi Kiran Koripella, Chenhui Huang, Måns Ehrenberg, Suparna Sanyal, Joachim Frank
Published 2013-06-01

Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex

by Sara Hernández-Ortega, Abril Sánchez-Botet, Eva Quandt, Núria Masip, Laura Gasa, Gaetano Verde, Javier Jiménez, Rebecca S. Levin, Florentine U. Rutaganira, Alma L. Burlingame, Don Wolfgeher, Mariana P. C. Ribeiro, Stephen J. Kron, Kevan M. Shokat, Josep Clotet
Published 2019-04-01

Hyper- and hypo- nutrition studies of the hepatic transcriptome and epigenome suggest that PPARα regulates anaerobic glycolysis

by Anthony R. Soltis, Shmulik Motola, Santiago Vernia, Christopher W. Ng, Norman J. Kennedy, Simona Dalin, Bryan J. Matthews, Roger J. Davis, Ernest Fraenkel
Published 2017-03-01

Characterization of universal features of partially methylated domains across tissues and species

by Benjamin E. Decato, Jianghan Qu, Xiaojing Ji, Elvin Wagenblast, Simon R. V. Knott, Gregory J. Hannon, Andrew D. Smith
Published 2020-10-01

Ribosome Profiling Reveals Pervasive Translation Outside of Annotated Protein-Coding Genes

by Nicholas T. Ingolia, Gloria A. Brar, Noam Stern-Ginossar, Michael S. Harris, Gaëlle J.S. Talhouarne, Sarah E. Jackson, Mark R. Wills, Jonathan S. Weissman
Published 2014-09-01

Bystander-Activated Memory CD8 T Cells Control Early Pathogen Load in an Innate-like, NKG2D-Dependent Manner

by Talyn Chu, Aaron J. Tyznik, Sarah Roepke, Amy M. Berkley, Amanda Woodward-Davis, Laura Pattacini, Michael J. Bevan, Dietmar Zehn, Martin Prlic
Published 2013-03-01

Crowdsourcing the creation of image segmentation algorithms for connectomics

by Ignacio eArganda-Carreras, Srinivas C Turaga, Daniel R Berger, Dan eCiresan, Alessandro eGiusti, Luca Maria Gambardella, Jürgen eSchmidhuber, Dmitry eLaptev, Sarvesh eDwivedi, Joachim M Buhmann, Ting eLiu, Mojtaba eSeyedhosseini, Tolga eTasdizen, Lee eKamentsky, Radim eBurget, Vaclav eUher, Xiao eTan, Cangming eSun, Tuan ePham, Erhan eBas, Mustafa Gokhan Uzunbas, Albert eCardona, Johannes eSchindelin, H. Sebastian eSeung
Published 2015-11-01

High-fidelity estimates of spikes and subthreshold waveforms from 1-photon voltage imaging in vivo

by Michael E. Xie, Yoav Adam, Linlin Z. Fan, Urs L. Böhm, Ian Kinsella, Ding Zhou, Marton Rozsa, Amrita Singh, Karel Svoboda, Liam Paninski, Adam E. Cohen
Published 2021-04-01

Reduction of Purkinje Cell Pathology in SCA1 Transgenic Mice by p53 Deletion

by Mona D. Shahbazian, Harry T. Orr, Huda Y. Zoghbi
Published 2001-12-01

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

by Yan Wang, Yongcheng Huang, Helen H. Hobbs, Jonathan C. Cohen
Published 2012-09-01

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

by Falk Liberta, Sarah Loerch, Matthies Rennegarbe, Angelika Schierhorn, Per Westermark, Gunilla T. Westermark, Bouke P. C. Hazenberg, Nikolaus Grigorieff, Marcus Fändrich, Matthias Schmidt
Published 2019-03-01

Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry

by Dorothy D. Majewski, Liam J. Worrall, Chuan Hong, Claire E. Atkinson, Marija Vuckovic, Nobuhiko Watanabe, Zhiheng Yu, Natalie C. J. Strynadka
Published 2019-02-01

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

by Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A. Deshpande, Yaakov Maman, Amanda Day, Tanya T. Paull, André Nussenzweig
Published 2020-02-01

In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A

by Hyun Ok Ham, Zheng Qu, Carolyn A. Haller, Brent M. Dorr, Erbin Dai, Wookhyun Kim, David R. Liu, Elliot L. Chaikof
Published 2016-04-01

Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin

by J. Hu, L. J. Worrall, C. Hong, M. Vuckovic, C. E. Atkinson, N. Caveney, Z. Yu, N. C. J. Strynadka
Published 2018-09-01

Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion

by Alexandra C. Title, Sue-Jean Hong, Nuno D. Pires, Lynn Hasenöhrl, Svenja Godbersen, Nadine Stokar-Regenscheit, David P. Bartel, Markus Stoffel
Published 2018-11-01

Controlling gain one photon at a time

by Gregory W Schwartz, Fred Rieke
Published 2013-05-01

Physiological and stem cell compartmentalization within the Drosophila midgut

by Alexis Marianes, Allan C Spradling
Published 2013-08-01

Sleeping Sickness: A Tale of Two Clocks

by Filipa Rijo-Ferreira, Filipa Rijo-Ferreira, Joseph S. Takahashi, Joseph S. Takahashi
Published 2020-10-01