An essential role for MEF2C in the cortical response to loss of sleep in mice

by Theresa E Bjorness, Ashwinikumar Kulkarni, Volodymyr Rybalchenko, Ayako Suzuki, Catherine Bridges, Adam J Harrington, Christopher W Cowan, Joseph S Takahashi, Genevieve Konopka, Robert W Greene
Published 2020-08-01

Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity

by Juan L Mendoza, Suzanne Fischer, Marvin H Gee, Lilian H Lam, Simon Brackenridge, Fiona M Powrie, Michael Birnbaum, Andrew J McMichael, K Christopher Garcia, Geraldine M Gillespie
Published 2020-07-01

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

by Ricardo A Fernandes, Chaoran Li, Gang Wang, Xinbo Yang, Christina S Savvides, Caleb R Glassman, Shen Dong, Eric Luxenberg, Leah V Sibener, Michael E Birnbaum, Christophe Benoist, Diane Mathis, K Christopher Garcia
Published 2020-08-01

Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

by Ray L Hong, Metta Riebesell, Daniel J Bumbarger, Steven J Cook, Heather R Carstensen, Tahmineh Sarpolaki, Luisa Cochella, Jessica Castrejon, Eduardo Moreno, Bogdan Sieriebriennikov, Oliver Hobert, Ralf J Sommer
Published 2019-09-01

Epigenetic inheritance of circadian period in clonal cells

by Yan Li, Yongli Shan, Gokhul Krishna Kilaru, Stefano Berto, Guang-Zhong Wang, Kimberly H Cox, Seung-Hee Yoo, Shuzhang Yang, Genevieve Konopka, Joseph S Takahashi
Published 2020-05-01

A single-cell survey of Drosophila blood

by Sudhir Gopal Tattikota, Bumsik Cho, Yifang Liu, Yanhui Hu, Victor Barrera, Michael J Steinbaugh, Sang-Ho Yoon, Aram Comjean, Fangge Li, Franz Dervis, Ruei-Jiun Hung, Jin-Wu Nam, Shannan Ho Sui, Jiwon Shim, Norbert Perrimon
Published 2020-05-01

Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

by Jay F Sarthy, Michael P Meers, Derek H Janssens, Jorja G Henikoff, Heather Feldman, Patrick J Paddison, Christina M Lockwood, Nicholas A Vitanza, James M Olson, Kami Ahmad, Steven Henikoff
Published 2020-09-01

Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

by Neel Shah, Ping Wang, John Wongvipat, Wouter R Karthaus, Wassim Abida, Joshua Armenia, Shira Rockowitz, Yotam Drier, Bradley E Bernstein, Henry W Long, Matthew L Freedman, Vivek K Arora, Deyou Zheng, Charles L Sawyers
Published 2017-09-01

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

by Wenbao Hu, Xiaojie Yu, Zhengzhao Liu, Ying Sun, Xibing Chen, Xin Yang, Xiaofen Li, Wai Kwan Lam, Yuanyuan Duan, Xu Cao, Hermann Steller, Kai Liu, Pingbo Huang
Published 2017-06-01

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

by Zachary Freyberg, Mark S. Sonders, Jenny I. Aguilar, Takato Hiranita, Caline S. Karam, Jorge Flores, Andrea B. Pizzo, Yuchao Zhang, Zachary J. Farino, Audrey Chen, Ciara A. Martin, Theresa A. Kopajtic, Hao Fei, Gang Hu, Yi-Ying Lin, Eugene V. Mosharov, Brian D. McCabe, Robin Freyberg, Kandatege Wimalasena, Ling-Wei Hsin, Dalibor Sames, David E. Krantz, Jonathan L. Katz, David Sulzer, Jonathan A. Javitch
Published 2016-02-01

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

by Brian T Emmer, Geoffrey G Hesketh, Emilee Kotnik, Vi T Tang, Paul J Lascuna, Jie Xiang, Anne-Claude Gingras, Xiao-Wei Chen, David Ginsburg
Published 2018-09-01

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

by Yvonne Vercoulen, Yasushi Kondo, Jeffrey S Iwig, Axel B Janssen, Katharine A White, Mojtaba Amini, Diane L Barber, John Kuriyan, Jeroen P Roose
Published 2017-09-01

Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau

by Maxime WC Rousseaux, Jean-Pierre Revelli, Gabriel E Vázquez-Vélez, Ji-Yoen Kim, Evelyn Craigen, Kristyn Gonzales, Jaclyn Beckinghausen, Huda Y Zoghbi
Published 2018-06-01

CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

by Hironobu Okuno, Francois Renault Mihara, Shigeki Ohta, Kimiko Fukuda, Kenji Kurosawa, Wado Akamatsu, Tsukasa Sanosaka, Jun Kohyama, Kanehiro Hayashi, Kazunori Nakajima, Takao Takahashi, Joanna Wysocka, Kenjiro Kosaki, Hideyuki Okano
Published 2017-11-01

Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways

by S Michael Rothenberg, Kyle Concannon, Sarah Cullen, Gaylor Boulay, Alexa B Turke, Anthony C Faber, Elizabeth L Lockerman, Miguel N Rivera, Jeffrey A Engelman, Shyamala Maheswaran, Daniel A Haber
Published 2015-02-01

Non-crossover gene conversions show strong GC bias and unexpected clustering in humans

by Amy L Williams, Giulio Genovese, Thomas Dyer, Nicolas Altemose, Katherine Truax, Goo Jun, Nick Patterson, Simon R Myers, Joanne E Curran, Ravi Duggirala, John Blangero, David Reich, Molly Przeworski, on behalf of the T2D-GENES Consortium
Published 2015-03-01

eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons

by Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Martina Sgritta, Wei Huang, Krešimir Krnjević, Randal J Kaufman, John A Dani, Peter Walter, Mauro Costa-Mattioli
Published 2016-12-01

The GARP complex is required for cellular sphingolipid homeostasis

by Florian Fröhlich, Constance Petit, Nora Kory, Romain Christiano, Hans-Kristian Hannibal-Bach, Morven Graham, Xinran Liu, Christer S Ejsing, Robert V Farese Jr, Tobias C Walther
Published 2015-09-01

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

by Jose U Scher, Andrew Sczesnak, Randy S Longman, Nicola Segata, Carles Ubeda, Craig Bielski, Tim Rostron, Vincenzo Cerundolo, Eric G Pamer, Steven B Abramson, Curtis Huttenhower, Dan R Littman
Published 2013-11-01

Ribosome•RelA structures reveal the mechanism of stringent response activation

by Anna B Loveland, Eugene Bah, Rohini Madireddy, Ying Zhang, Axel F Brilot, Nikolaus Grigorieff, Andrei A Korostelev
Published 2016-07-01