Animals Article Bagg albino mouse Biomarkers, Tumor CCR7 CCR7 protein, human Cell Hypoxia Cell Line, Tumor Female HIF-1α Head and Neck Neoplasms Head and neck cancer Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit Mice Mice, Inbred BALB C Mice, Nude OSC-19 cell line Receptors, CCR7 Tumour grade Tumour stage animal animal experiment animal model cancer cell culture cell hypoxia chemokine receptor CCR7 controlled study female