Mechanistic insights into acyclovir-polyethylene glycol 20000 binary dispersions

Mechanistic insights into acyclovir-polyethylene glycol 20000 binary dispersions

Objective: The objective of this study is to provide a mechanistic insight into solubility enhancement and dissolution of acyclovir (ACY) by polyethylene glycol20000 (PEG20000). Materials and Methods: Solid dispersions with differing ratios of drug (ACY) and carrier (PEG20000) were prepared and eval...

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Bibliographic Details
Main Authors: Gunasunderi, R (Author), Kai, HW (Author), Kassen, K (Author), Nayak, MM (Author), Parasuraman, S (Author), Shah, SAA (Author), Sureshkumar, K (Author), Venkateskumar, K (Author)
Format: Article
Language:English
Published: 2016
Subjects:
Acyclovir
BIOAVAILABILITY
crystallinity
DISSOLUTION RATE
drug-polymer miscibility
ENHANCEMENT
PHYSICOCHEMICAL CHARACTERIZATION
RELEASE
solid dispersions
SOLID DISPERSIONS
solid solution
SOLUBILITY
STABILITY
SYSTEMS
WATER-SOLUBLE DRUGS
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