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01554nam a2200169Ia 4500 |
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10.3136-fstr.18.549 |
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220124s2012 CNT 000 0 und d |
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|a 1344-6606
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|a 1881-3984
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|a Enhanced Oral Bioavailability of Astaxanthin with Droplet Size Reduction
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|a FOOD SCIENCE AND TECHNOLOGY RESEARCH
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.3136/fstr.18.549
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3 |
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|a Astaxanthin is a natural xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influence of emulsion droplet size on astaxanthin bioavailability is yet to be studied. This study was performed to investigate the effects of emulsion droplet size reduction on the bioavailability of astaxanthin emulsion through oral administration. In viva study was carried out to evaluate the rate and extent of absorption of macro and nanosized emulsion an oil solution formulation. The nanosized emulsion shows increased C-max and AUC(0-infinity) and decreased T-max values with a reduction of the emulsion globule size. The AUC(0-infinity) of nanosized compared to macrosized emulsion and oil solution was increased by 110% - 140% and 140% - 200% respectively.
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|a Affandi, MMRMM
|e author
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1 |
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|a Julianto, T
|e author
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|a Majeed, ABA
|e author
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| 773 |
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|t FOOD SCIENCE AND TECHNOLOGY RESEARCH
|x 1881-3984
|g 18 4, 549-554
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