Biopurification of monoclonal antibody (mAb) through crystallisation

Biopurification of monoclonal antibody (mAb) through crystallisation

Therapeutics based on monoclonal antibody (mAb) represent the most advanced biopharmaceuticals, being able to treat a wide range of challenging diseases such as cancers and arthritis. As the scale of mAb production steadily increases with the demand for mAb-based therapeutics, the downstream biopuri...

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Bibliographic Details
Main Authors: Chen, WQ (Author), Guo, MX (Author), Heng, JYY (Author), Li, XY (Author), Link, FJ (Author), Ouyang, JB (Author), Ramli, SS (Author), Rosbottom, I (Author)
Format: Article
Language:English
Published: 2021
Subjects:
Biopurification
EGG-WHITE
HETEROGENEOUS NUCLEATION
HOFMEISTER SERIES
HOST-CELL PROTEIN
HUMAN-IGG
LIQUID-PHASE-SEPARATION
Monoclonal antibody
Phase behaviour
POLISHING STEPS
PROTEIN CRYSTAL NUCLEATION
Protein crystallisation
Scale-up
SUPERSATURATED LYSOZYME SOLUTIONS
SURFACE-CHEMISTRY
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