Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers
Background The MDM2 gene encodes a negative regulator of the p53 tumour suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce accelerated tumour formation in individuals with inherited p53 mutations. We hav...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2006-03-24.
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| Subjects: | |
| Online Access: | Get fulltext |