Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy
Despite antigen engagement and intact B-cell-receptor (BCR) signaling, chronic lymphocytic leukemia (CLL) cells fail to undergo terminal differentiation. We hypothesized that such failure may be due to anergy, as CLL cells exhibit variable levels of nonresponsiveness to surface IgM stimulation that...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014-05-22.
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| Subjects: | |
| Online Access: | Get fulltext |