DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint
Extensive damage to maternal DNA during meiosis causes infertility, birth defects and abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the creation of DNA-damaged embryos. Here we show that DNA damage activates a pathway involving the spindle assembly checkpoint (...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2015-11-02.
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| Subjects: | |
| Online Access: | Get fulltext |