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01541 am a22002413u 4500 |
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376116 |
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|a Calvo, Ana C.
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|a Moreno-Igoa, María
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|a Mancuso, Renzo
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|a Manzano, Raquel
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|a Oliván, Sara
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|a Muñoz, María J.
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|a Penas, Clara
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|a Zaragoza, Pilar
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|a Navarro, Xavier
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|a Osta, Rosario
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|a Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule
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|c 2011-03.
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|z Get fulltext
|u https://eprints.soton.ac.uk/376116/1/art%25253A10.1186%25252F1750-1172-6-10.pdf_token2%253Dexp%253D1429872606%257Eacl%253D%25252Fstatic%25252Fpdf%25252F499%25252Fart%2525253A10.1186%2525252F1750-1172-6-10.pdf_%257Ehmac%253D9798589e7b1a1224ac0295798711fd3d564dca56ab822fdf3d78bc5f576cc8e9
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|a Significant improvements in behavioral and electrophysiological results, motoneuron survival and anti-apoptotic/survival-activated pathways were observed with BDNF-TTC treatment. However, no synergistic effect was found for this fusion molecule. Although BDNF in the fusion molecule is capable of activating autocrine and neuroprotective pathways, TTC treatment alone yielded similar neuroprotection. Therefore, an accurate study of the neuroprotective effects of TTC fusion molecules should be performed to obtain a better understanding of its effects
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