Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis

Sporadic and familiar amyotrophic lateral sclerosis (ALS) cases presented lower cholinergic activity than in healthy individuals in their still preserved spinal motoneurons (MNs) suggesting that cholinergic reduction might occur before MN death. To unravel how and when cholinergic function is compro...

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Bibliographic Details
Main Authors: Casas, C. (Author), Herrando-Grabulosa, M. (Author), Manzano, R. (Author), Mancuso, Renzo (Author), Osta, R. (Author), Navarro, X. (Author)
Format: Article
Language:English
Published: 2013-02-17.
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