Tetrafluorination of sugars as strategy for enhancing protein-carbohydrate affinity: application to UDP-Galp mutase inhibition
Tetrafluorinated analogues of both UDP-galactosylpyranose and UDP-galactosylfuranose have been synthesized and assayed against UDP-galactopyranose mutase, a key enzyme of M. tuberculosis cell wall biosynthesis. Competition assays and STD-NMR techniques have evidenced not only the first unambiguous c...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014-01-03.
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| Subjects: | |
| Online Access: | Get fulltext Get fulltext |