The synthesis of mono- and difluorinated 2,3-dideoxy-d-glucopyranoses

by Mtashobya, Lewis, Quiquempoix, Lucas, Linclau, Bruno
Published 2015

A linear synthesis of gemcitabine

by Brown, Kylie, Weymouth-Wilson, Alex, Linclau, Bruno
Published 2015

The synthesis of tetrafluorinated aminosugars

by Fontenelle, Clément Q., Tizzard, Graham J., Linclau, Bruno
Published 2014

The synthesis of gemcitabine

by Brown, Kylie, Dixey, Michael, Weymouth-Wilson, Alex, Linclau, Bruno
Published 2014

Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation

by Despiau, Carole F., Dominey, Andrew P., Harrowven, David C., Linclau, Bruno
Published 2014

Disubstituted bis-THF moieties as new P2 ligands in nonpeptidal HIV-1 protease inhibitors (II)

by Hohlfeld, Konrad, Wegner, Jörg Kurt, Kesteleyn, Bart, Linclau, Bruno, Unge, Johan
Published 2015

Stereoselectivity of the Honda-Reformatsky reaction in reactions with ethyl bromodifluoroacetate with ?-oxygenated sulfinylimines

by Fontenelle, Clément Q., Conroy, Matthew, Light, Mark, Poisson, Thomas, Pannecoucke, Xavier, Linclau, Bruno
Published 2014

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase

by Ioannou, Avgousta, Cini, Elena, Timofte, Roxana S., Flitsch, Sabine L., Turner, Nicholas J., Linclau, Bruno
Published 2011

An unexpected and significantly lower hydrogen-bond-donating capacity of fluorohydrins compared to nonfluorinated alcohols. [VIP paper]

by Graton, Jérôme, Wang, Zhong, Brossard, Anne-Marie, Gonçalves Monteiro, Daniela, Le Questel, Jean-Yves, Linclau, Bruno
Published 2012

Stereocontrol by quaternary centres: a stereoselective synthesis of (?)-luminacin D

by Bartlett, Nathan, Gross, Leona, Péron, Florent, Asby, Daniel J., Selby, Matthew D., Tavassoli, Ali, Linclau, Bruno
Published 2014

Investigating the influence of (Deoxy)fluorination on the lipophilicity of non-UV-active fluorinated alkanols and carbohydrates by a new log P determination method

by Linclau, Bruno, Wang, Zhong, Compain, Guillaume, Paumelle, Vincent, Fontenelle, Clement Q., Wells, Neil, Weymouth-Wilson, Alex
Published 2016

Tetrafluorination of sugars as strategy for enhancing protein-carbohydrate affinity: application to UDP-Galp mutase inhibition

by N'Go, Inès, Golten, Samuel, Ardá, Ana, Cañada, Javier, Jiménez-Barbero, Jesús, Linclau, Bruno, Vincent, Stéphane P.
Published 2014

Influence of fluorination on the conformational properties and hydrogen-bond acidity of benzyl alcohol derivatives

by Bogdan, Elena, Compain, Guillaume, Mtashobya, Lewis, Le Questel, Jean-Yves, Besseau, François, Galland, Nicolas, Linclau, Bruno, Graton, Jérôme
Published 2015

A computational study of vicinal fluorination in 2,3-difluorobutane: implications for conformational control in alkane chains

by Fox, Stephen J., Gourdain, Stephanie, Coulthurst, Anton, Fox, Claire, Kuprov, Ilya, Essex, Jonathan W., Skylaris, Chris-Kriton, Linclau, Bruno
Published 2015

Invariant NKT cells promote CD8(+) cytotoxic T cell responses by inducing CD70 expression on dendritic cells

by Taraban, Vadim Y., Martin, Sonya, Attfield, Kathrine E., Glennie, Martin J., Elliott, Tim, Elewaut, Dirk, Van Calenbergh, Serge, Linclau, Bruno, Al-Shamkhani, Aymen
Published 2008

Intramolecular OH···fluorine hydrogen bonding in saturated, acyclic fluorohydrins: the γ-fluoropropanol motif

by Linclau, Bruno, Peron, Florent, Bogdan, Elena, Wells, Neil, Wang, Zhong, Compain, Guillaume, Fontenelle, Clement Q., Galland, Nicolas, Le Questel, Jean-Yves, Graton, Jérôme
Published 2015

Structural basis of ligand binding to UDP-galactopyranose mutase from mycobacterium tuberculosis using substrate and tetrafluorinated substrate analogs

by van Straaten, Karin E., A. Kuttiyatveetil, Jijin R., Sevrain, Charlotte M., Villaume, Sydney A., Jimenez-Barbero, Jesus, Linclau, Bruno, Vincent, Stéphane P., Sanders, David A.R
Published 2015