In vitro supplementation with dAMP/dGMP leads to partial restoration of mtDNA levels in mitochondrial depletion syndromes
Mitochondrial DNA depletion syndrome, a frequent cause of childhood (hepato)encephalomyopathies, is defined as a reduction of mitochondrial DNA copy number related to nuclear DNA. It was previously shown that mtDNA depletion can be prevented by dAMP/dGMP supplementation in deoxyguanosine kinase-defi...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
2009-02-16.
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Subjects: | |
Online Access: | Get fulltext |