In vitro supplementation with dAMP/dGMP leads to partial restoration of mtDNA levels in mitochondrial depletion syndromes

Mitochondrial DNA depletion syndrome, a frequent cause of childhood (hepato)encephalomyopathies, is defined as a reduction of mitochondrial DNA copy number related to nuclear DNA. It was previously shown that mtDNA depletion can be prevented by dAMP/dGMP supplementation in deoxyguanosine kinase-defi...

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Bibliographic Details
Main Authors: Bulst, Stefanie (Author), Abicht, Angela (Author), Holinski-Feder, Elke (Author), Mueller-Ziermann, Solvig (Author), Koehler, Udo (Author), Thirion, Christian (Author), Walter, Maggie C. (Author), Stewart, Joanna D. (Author), Chinnery, Patrick F. (Author), Lochmueller, Hanns (Author), Horvath, Rita (Author)
Format: Article
Language:English
Published: 2009-02-16.
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