Crystallographic studies on two bioisosteric analogues, N-acetyl-b-D-glucopyranosylamine and N-trifluoroacetyl-b-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase
Structure-based inhibitor design has led to the discovery of a number of potent inhibitors of glycogen phosphorylase b GPb), N-acyl derivatives of b-D-glucopyranosylamine, that bind at the catalytic site of the enzyme. The first good inhibitor in this class of compounds, N-acetyl-b-D-glucopyranosyla...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2006.
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| Subjects: | |
| Online Access: | Get fulltext |