Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

Background Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin treatment. In most, the cause is unknown. Because ATP-sensitive potassium (KATP) channels mediate glucose-stimulated insulin secretion from the pancreatic beta cells, we hyp...

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Main Authors: Gloyn, Anna L. (Author), Pearson, Ewan R. (Author), Antcliff, Jennifer F. (Author), Proks, Peter (Author), Bruining, Jan (Author), Slingerland, Annabelle S. (Author), Howard, Neville (Author), Srinivasan, Shubha (Author), Silva, José M.C.L (Author), Molnes, Janne (Author), Edghill, Emma L. (Author), Frayling, Timothy M. (Author), Temple, I. Karen (Author), Mackay, Deborah (Author), Shield, Julain P.H (Author), Sumnik, Zdenek (Author), Van Rhijn, Adrian (Author), Wales, J.erry K.H (Author), Clark, Penelope (Author), Gorman, Shaun (Author), Aisenberg, Javier (Author), Ellard, Sian (Author), Njolstad, Pal R. (Author), Ashcroft, Frances M. (Author), Hattersley, Andrew T. (Author)
Format: Article
Language:English
Published: 2004-04-29.
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