The structure of the C-C bond hydrolase MhpC provides insights into its catalytic mechanism

2-Hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase (MhpC) is a 62 kDa homodimeric enzyme of the phenylpropionate degradation pathway of Escherichia coli. The 2.1 Å resolution X-ray structure of the native enzyme determined from orthorhombic crystals confirms that it is a member of the ?/?...

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Main Authors: Dunn, G. (Author), Montgomery, M.G (Author), Mohammed, F. (Author), Coker, A. (Author), Cooper, J.B (Author), Robertson, T. (Author), Garcia, J.L (Author), Bugg, T.D.H (Author), Wood, S.P (Author)
Format: Article
Language:English
Published: 2005-02-11.
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