Mathematical modeling predicts synergistic antitumor effects of combining a macrophage-based, hypoxia-targeted gene therapy with chemotherapy
Tumor hypoxia is associated with low rates of cell proliferation and poor drug delivery, limiting the efficacy of many conventional therapies such as chemotherapy. Because many macrophages accumulate in hypoxic regions of tumors, one way to target tumor cells in these regions could be to use genetic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2011-03.
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| Subjects: | |
| Online Access: | Get fulltext |