Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase

• Main Authors: Ioannou, Avgousta (Author), Cini, Elena (Author), Timofte, Roxana S. (Author), Flitsch, Sabine L. (Author), Turner, Nicholas J. (Author), Linclau, Bruno (Author)
• Format: Article
• Language: English
• Published: 2011-09-13.
• Subjects: Article
• Online Access: Get fulltext

Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar