Synergistic amplification of beta-amyloid-and interferon-?-induced microglial neurotoxic response by the senile plaque component chromogranin A

Synergistic amplification of beta-amyloid-and interferon-?-induced microglial neurotoxic response by the senile plaque component chromogranin A

Activation of the microglial neurotoxic response by components of the senile plaque plays a critical role in the pathophysiology of Alzheimer's disease (AD). Microglia induce neurodegeneration primarily by secreting nitric oxide (NO), tumor necrosis factor-? (TNF?), and hydrogen peroxide. Centr...

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Bibliographic Details
Main Authors: Twig, Gilad (Author), Graf, Solomon A. (Author), Messerli, Mark A. (Author), Smith, Peter J.S (Author), Yoo, Seung H. (Author), Shirihai, Orian S. (Author)
Format: Article
Language:English
Published: 2005-01.
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