Synergistic amplification of beta-amyloid-and interferon-?-induced microglial neurotoxic response by the senile plaque component chromogranin A
Activation of the microglial neurotoxic response by components of the senile plaque plays a critical role in the pathophysiology of Alzheimer's disease (AD). Microglia induce neurodegeneration primarily by secreting nitric oxide (NO), tumor necrosis factor-? (TNF?), and hydrogen peroxide. Centr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2005-01.
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| Subjects: | |
| Online Access: | Get fulltext |