Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
Background Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion. Addressing the therapeutic potential of modulating...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2009.
|
| Subjects: | |
| Online Access: | Get fulltext |