Genomic characterization of a new endophytic Streptomyces kebangsaanensis identifies biosynthetic pathway gene clusters for novel phenazine antibiotic production

Genomic characterization of a new endophytic Streptomyces kebangsaanensis identifies biosynthetic pathway gene clusters for novel phenazine antibiotic production

Background. Streptomyces are well known for their capability to produce many bioac- tive secondary metabolites with medical and industrial importance. Here we report a novel bioactive phenazine compound, 6-((2-hydroxy-4-methoxyphenoxy) carbonyl) phenazine-1-carboxylic acid (HCPCA) extracted from Str...

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Bibliographic Details
Main Authors: Aizat, W.M (Author), Keong, L.K (Author), Ng, C.L (Author), Remali, J. (Author), Sarmin, N.I.M (Author), Tiong, J.J.L (Author), Zin, N.M (Author)
Format: Article
Language:English
Published: PeerJ Inc. 2017
Subjects:
6 [(2 hydroxy 4 methoxyphenoxy) carbonyl] phenazine 1carboxylic acid
antibiotic agent
antibiotic resistance
Article
bioinformatics
biosynthesis
chemical structure
DNA base composition
gene cluster
gene ontology
gene sequence
genetic analysis
Genomic
liquid chromatography
metabolite
molecular genetics
nuclear magnetic resonance spectroscopy
phenazine
Phenazine
Portulaca oleracea
Portulaca oleracea extract
proton nuclear magnetic resonance
S. kebangsaanensis
Secondary metabolites
sequence alignment
Streptomyces
Streptomyces kebangsaanensis
unclassified drug
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