Main Manuscript for Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation

Main Manuscript for Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation

Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin (TTP)-directed mRNA deadenylation destabilizes AU-rich element (ARE)-containing...

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Bibliographic Details
Main Authors: Caballé, A. (Author), Calderone, V. (Author), Castellazzi, C.L (Author), Díez, J. (Author), Dotu, I. (Author), Martín, J. (Author), Méndez, R. (Author), Nebreda, A.R (Author), Reina, O. (Author), Rivas, E. (Author), Sibilio, A. (Author), Suñer, C. (Author)
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022
Subjects:
CPEBs
MAPK signaling
mRNA stability
RNA binding protein
TTP
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