Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-substituted pyrrolidines using NaBH4/AcOH and heterogenous hydrogenation reactions

Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-substituted pyrrolidines using NaBH4/AcOH and heterogenous hydrogenation reactions

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Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidine 1 by NaBH4/AcOH and heterogenous hydrogenation were reported. Stereochemical assignment and diastereomeric ratios of the products were determined using 1H NMR and single crystal X-ray analyses. The steric factors of the C...

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Bibliographic Details
Main Authors:	Hamzah, A.S (Author), Mansor, N.S (Author), Mohammat, M.F (Author), Shaameri, Z. (Author)
Format:	Article
Language:	English
Published:	Korean Chemical Society 2015
Subjects:	2,3-Dioxo-pyrrolidine Diastereomeric ratios Diastereoselective Diastereoselective reduction Diastereo-selectivity Enol reduction Hydrogenation Hydrogenation reactions Pyrrolidinone Single crystal X-ray analysis Single crystals Stereoselectivity X ray analysis
Online Access:	View Fulltext in Publisher View in Scopus

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