Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-substituted pyrrolidines using NaBH4/AcOH and heterogenous hydrogenation reactions

Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-substituted pyrrolidines using NaBH4/AcOH and heterogenous hydrogenation reactions

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Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidine 1 by NaBH4/AcOH and heterogenous hydrogenation were reported. Stereochemical assignment and diastereomeric ratios of the products were determined using 1H NMR and single crystal X-ray analyses. The steric factors of the C...

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Bibliographic Details
Main Authors: Hamzah, A.S (Author), Mansor, N.S (Author), Mohammat, M.F (Author), Shaameri, Z. (Author)
Format: Article
Language:English
Published: Korean Chemical Society 2015
Subjects:
2,3-Dioxo-pyrrolidine
Diastereomeric ratios
Diastereoselective
Diastereoselective reduction
Diastereo-selectivity
Enol reduction
Hydrogenation
Hydrogenation reactions
Pyrrolidinone
Single crystal X-ray analysis
Single crystals
Stereoselectivity
X ray analysis
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