3D cell culture alters signal transduction and drug response in head and neck squamous cell carcinoma

Epidermal growth factor receptor (EGFR) upregulation is a typical characteristic of head and neck squamous cell carcinoma (HNSCC). However, tyrosine kinase inhibitors have not yet been able to achieve enough therapeutic benefit in clinical trials to justify their use in standard therapy regimens. At...

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Bibliographic Details
Main Authors: Affolter, A. (Author), Heid, J. (Author), Jakob, Y. (Author), Kern, J. (Author), Lammert, A. (Author), Rotter, N. (Author), Tenschert, E. (Author)
Format: Article
Language:English
Published: Spandidos Publications 2022
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Online Access:View Fulltext in Publisher