Genetic variability in exon 1 of the glucocorticoid receptor gene NR3C1 is associated with postoperative complications

Genetic variability in exon 1 of the glucocorticoid receptor gene NR3C1 is associated with postoperative complications

Patients undergoing major surgery experience postoperative inflammation, which may contribute to postoperative morbidity. Endogenous glucocorticoids (GCs) are an essential part of the stress response, but this response varies between individuals, which may in turn affect clinical outcome and specifi...

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Bibliographic Details
Main Authors: Bergman, E.A (Author), Gråberg, T. (Author), Sjöholm, L.K (Author), Strömmer, L. (Author), Wikström, A.-C (Author), Winerdal, M. (Author), Winqvist, O. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
adult
Adult
aged
Aged
Aged, 80 and over
DNA methylation
DNA Methylation
epigenetics
exon
Exons
female
Female
genetics
glucocorticoid
glucocorticoid receptor
Glucocorticoids
human
Humans
inflammation
Inflammation
male
Male
metabolism
middle aged
Middle Aged
NR3C1 protein, human
nuclear receptor subfamily 3 group C member 1
postoperative complication
postoperative complications
Postoperative Complications
Receptors, Glucocorticoid
single nucleotide polymorphisms
surgery
very elderly
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