Delta- and gamma-tocotrienol isomers are potent in inhibiting inflammation and endothelial activation in stimulated human endothelial cells

Delta- and gamma-tocotrienol isomers are potent in inhibiting inflammation and endothelial activation in stimulated human endothelial cells

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Background: Tocotrienols (TCTs) are more potent antioxidants than α-tocopherol (TOC). However, the effectiveness and mechanism of the action of TCT isomers as anti-atherosclerotic agents in stimulated human endothelial cells under inflammatory conditions are not well established. Aims: 1) To compare...

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Bibliographic Details
Main Authors: Anisah Froemming, G.R (Author), Manaf Ali, A. (Author), Muid, S. (Author), Nawawi, H.M (Author), Rahman, T. (Author)
Format: Article
Language:English
Published: Co-Action Publishing 2016
Subjects:
alpha tocotrienol
antiatherosclerotic activity
antiinflammatory activity
area under the curve
Article
beta tocotrienol
capillary endothelial cell
cardiovascular agent
cell stimulation
concentration response
controlled study
cytokine release
delta tocotrienol
drug activity
drug mechanism
drug potency
Endothelial activation
endothelial leukocyte adhesion molecule 1
endothelial nitric oxide synthase
gamma tocotrienol
gene expression
human
human cell
immunoglobulin enhancer binding protein
incubation time
Inflammation
intercellular adhesion molecule 1
interleukin 6
lipopolysaccharide
messenger RNA
molecular dynamics
MTT assay
NFκB; endothelial cells
protein expression
protein secretion
tocopherol
tocopherol derivative
Tocotrienols
tumor necrosis factor
umbilical vein endothelial cell
unclassified drug
vascular cell adhesion molecule 1
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