Protective effects of Centella asiatica on cognitive deficits induced by D-gal/AlCl3 via inhibition of oxidative stress and attenuation of acetylcholinesterase level

Protective effects of Centella asiatica on cognitive deficits induced by D-gal/AlCl3 via inhibition of oxidative stress and attenuation of acetylcholinesterase level

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cholinergic dysfunctions and impaired redox homeostasis. The plant Centella asiatica (CA) is renowned for its nutritional benefits and herbal formulas for promoting health, enhancing cognition, and its neuroprotective eff...

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Bibliographic Details
Main Authors:	Adenan, M.I (Author), Amom, Z. (Author), Baharuldin, M.T.H (Author), Chiroma, S.M (Author), Jagadeesan, S. (Author), Mahdi, O. (Author), Moklas, M.A.M (Author), Taib, C.N.M (Author)
Format:	Article
Language:	English
Published:	MDPI AG 2019
Subjects:	acetylcholinesterase Acetylcholinesterase aluminum chloride Alzheimer's disease animal experiment animal model Article attenuation brain cortex Centella asiatica Centella asiatica extract cognitive defect Cognitive deficit controlled study donepezil enzyme activity enzyme inhibition enzyme linked immunosorbent assay ethology galactose hippocampus male malonaldehyde mitochondrion Morphological aberration Morris water maze test nonhuman oxidative stress Oxidative stress prefrontal cortex protein phosphorylation rat superoxide dismutase tau protein transmission electron microscopy ultrastructure
Online Access:	View Fulltext in Publisher View in Scopus

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