Protective effects of Centella asiatica on cognitive deficits induced by D-gal/AlCl3 via inhibition of oxidative stress and attenuation of acetylcholinesterase level

Protective effects of Centella asiatica on cognitive deficits induced by D-gal/AlCl3 via inhibition of oxidative stress and attenuation of acetylcholinesterase level

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cholinergic dysfunctions and impaired redox homeostasis. The plant Centella asiatica (CA) is renowned for its nutritional benefits and herbal formulas for promoting health, enhancing cognition, and its neuroprotective eff...

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Bibliographic Details
Main Authors: Adenan, M.I (Author), Amom, Z. (Author), Baharuldin, M.T.H (Author), Chiroma, S.M (Author), Jagadeesan, S. (Author), Mahdi, O. (Author), Moklas, M.A.M (Author), Taib, C.N.M (Author)
Format: Article
Language:English
Published: MDPI AG 2019
Subjects:
acetylcholinesterase
Acetylcholinesterase
aluminum chloride
Alzheimer's disease
animal experiment
animal model
Article
attenuation
brain cortex
Centella asiatica
Centella asiatica extract
cognitive defect
Cognitive deficit
controlled study
donepezil
enzyme activity
enzyme inhibition
enzyme linked immunosorbent assay
ethology
galactose
hippocampus
male
malonaldehyde
mitochondrion
Morphological aberration
Morris water maze test
nonhuman
oxidative stress
Oxidative stress
prefrontal cortex
protein phosphorylation
rat
superoxide dismutase
tau protein
transmission electron microscopy
ultrastructure
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