Aqueous partition of methanolic extract of Dicranopteris linearis leaves protects against liver damage induced by paracetamol

Aqueous partition of methanolic extract of Dicranopteris linearis leaves protects against liver damage induced by paracetamol

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This study aimed to determine the antioxidant and hepatoprotective activities of semi-purified aqueous partition obtained from the methanol extract of Dicranopteris linearis (AQDL) leaves against paracetamol (PCM)-induced liver intoxication in rats. The test solutions, AQDL (50, 250, and 500 mg/kg),...

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Bibliographic Details
Main Authors:	Kamisan, F.H (Author), Nasir, N.M (Author), Salleh, M.O (Author), Teh, L.K (Author), Zakaria, Z.A (Author)
Format:	Article
Language:	English
Published:	MDPI AG 2019
Subjects:	Acetaminophen alanine aminotransferase animal animal experiment animal model animal tissue Animals antioxidant antioxidant activity Antioxidants Article aspartate aminotransferase bilirubin biochemical analysis blood sampling body weight catalase Chemical and Drug Induced Liver Injury chemistry controlled study Dicranopteris linearis Dicranopteris linearis extract DPPH radical scavenging assay drug effect Endogenous antioxidant enzymes fern Free radical scavenging activity Hepatoprotective histopathology IC50 lipoxygenase liver Liver liver injury liver protection liver toxicity liver weight male Male malonaldehyde metabolism nonhuman oxygen radical absorbance capacity paracetamol phenol Phenolic derivatives phytochemical plant extract Plant Extracts plant leaf Plant Leaves rat Rats Rats, Sprague-Dawley saponin Saponins Sprague Dawley rat superoxide dismutase toxic hepatitis Tracheophyta triterpene Triterpenes unclassified drug vascular plant xanthine oxidase
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