Aqueous partition of methanolic extract of Dicranopteris linearis leaves protects against liver damage induced by paracetamol

Aqueous partition of methanolic extract of Dicranopteris linearis leaves protects against liver damage induced by paracetamol

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This study aimed to determine the antioxidant and hepatoprotective activities of semi-purified aqueous partition obtained from the methanol extract of Dicranopteris linearis (AQDL) leaves against paracetamol (PCM)-induced liver intoxication in rats. The test solutions, AQDL (50, 250, and 500 mg/kg),...

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Bibliographic Details
Main Authors: Kamisan, F.H (Author), Nasir, N.M (Author), Salleh, M.O (Author), Teh, L.K (Author), Zakaria, Z.A (Author)
Format: Article
Language:English
Published: MDPI AG 2019
Subjects:
Acetaminophen
alanine aminotransferase
animal
animal experiment
animal model
animal tissue
Animals
antioxidant
antioxidant activity
Antioxidants
Article
aspartate aminotransferase
bilirubin
biochemical analysis
blood sampling
body weight
catalase
Chemical and Drug Induced Liver Injury
chemistry
controlled study
Dicranopteris linearis
Dicranopteris linearis extract
DPPH radical scavenging assay
drug effect
Endogenous antioxidant enzymes
fern
Free radical scavenging activity
Hepatoprotective
histopathology
IC50
lipoxygenase
liver
Liver
liver injury
liver protection
liver toxicity
liver weight
male
Male
malonaldehyde
metabolism
nonhuman
oxygen radical absorbance capacity
paracetamol
phenol
Phenolic derivatives
phytochemical
plant extract
Plant Extracts
plant leaf
Plant Leaves
rat
Rats
Rats, Sprague-Dawley
saponin
Saponins
Sprague Dawley rat
superoxide dismutase
toxic hepatitis
Tracheophyta
triterpene
Triterpenes
unclassified drug
vascular plant
xanthine oxidase
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