Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3‐Ring‐E3 Ligase (CRL3) Dynamic Regulation and Cycling

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3‐Ring‐E3 Ligase (CRL3) Dynamic Regulation and Cycling

Cullin 3 (CUL3) is the scaffold of Cullin3 Ring E3‐ligases (CRL3s), which use various BTBadaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a delet...

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Bibliographic Details
Main Authors: Abdel‐khalek, W. (Author), Clauser, E. (Author), Gautreau, A.M (Author), Jeunemaitre, X. (Author), Kouranti, I. (Author), Loisel‐ferreira, I. (Author), Mazurkiewicz, S. (Author), Pintard, L. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
BTB protein
CRL complex
Cullin
interactome
WNK kinase
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