Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1β Induced Connexin 43 Upregulation and Gap Junction Communication in Urothelial Cells

Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1β Induced Connexin 43 Upregulation and Gap Junction Communication in Urothelial Cells

Bladder inflammatory diseases cause various urinary symptoms, such as urinary frequency and painful urination, that impair quality of life. In this study, we used a mouse model of cyclophos-phamide (CYP)-induced bladder inflammation and immortalized human urothelial (TRT-HU1) cells to explore the pr...

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Bibliographic Details
Main Authors: Kobayashi, T. (Author), Kono, J. (Author), Negoro, H. (Author), Ogawa, O. (Author), Sengiku, A. (Author), Suadicani, S.O (Author), Ueda, M. (Author), Woo, J.T (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
bladder inflammatory diseases
connexin 43
gap junction
nobiletin
urothelium
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