Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody

Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody

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Tetanus and Botulinum type B neurotoxins are bacterial metalloproteases that specifically cleave the vesicle-associated membrane protein VAMP at an identical peptide bond, resulting in inhibition of neuroexocytosis. The minute amounts of these neurotoxins commonly used in experimental animals are no...

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Bibliographic Details
Main Authors: Binz, T. (Author), Fabris, F. (Author), Matak, I. (Author), Montecucco, C. (Author), Pirazzini, M. (Author), Rossetto, O. (Author), Simonato, M. (Author), Šoštarić, P. (Author), Toffan, A. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
botulinum neurotoxins
polyclonal antibodies
SNARE proteins
tetanus neurotoxins
vesicle-associated membrane protein VAMP
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