AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia

AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia

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Neuroblastoma is the most common extracranial solid tumor of childhood, with heterogeneous clinical manifestations ranging from spontaneous regression to aggressive metastatic disease. The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that senses plasmatic fluctuation in the...

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Main Authors: Carcaboso, A.M (Author), Ecker, R.C (Author), Garcia, M. (Author), Gómez-González, S. (Author), Gonçalves-Alves, E. (Author), Lavarino, C. (Author), Mateo-Lozano, S. (Author), Mora, J. (Author), Muñoz-Aznar, O. (Author), Rodríguez-Hernández, C.J (Author), Suñol, M. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
AC-265347
biased signaling
calcimimetic
calcium-sensing receptor
cancer-testis antigens
cinacalcet
differentiation
neuroblastoma
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