Structural Study of the Complex of cblC Methylmalonic Aciduria and Homocystinuria-Related Protein MMACHC with Cyanocobalamin

Structural Study of the Complex of cblC Methylmalonic Aciduria and Homocystinuria-Related Protein MMACHC with Cyanocobalamin

MMACHC is an essential protein for the body to metabolise vitamin B12, and its deficiency will cause cblC-type methylmalonic aciduria and homocystinuria. MMACHC can interact with cyanocobalamin (a type of vitamin B12) cofactor and plays an important role in targeting cyanocobal-amin to the enzyme of...

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Bibliographic Details
Main Authors: He, J. (Author), Li, M. (Author), Wang, Q. (Author), Wang, W. (Author), Xu, M. (Author), Xu, Q. (Author), Yu, F. (Author), Zhang, C. (Author), Zhou, H. (Author), Zhu, Z. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
complex structure
cyanocobalamin
MMACHC
vitamin B12
X-ray diffraction
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