In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds

In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds

Some clinical studies have indicated activity of ivermectin, a macrocyclic lactone, against COVID-19, but a biological mechanism initially proposed for this anti-viral effect is not applicable at physiological concentrations. This in silico investigation explores potential modes of action of ivermec...

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Bibliographic Details
Main Authors: Aminpour, M. (Author), Cannariato, M. (Author), Deriu, M.A (Author), Donato, F. (Author), Doria, D. (Author), Moracchiato, A. (Author), Preto, J. (Author), Safaeeardebili, M.E (Author), Santin, A.D (Author), Scheim, D.E (Author), Tuszynski, J.A (Author), Zizzi, E.A (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
alpha-7 nicotinic receptor
CD147
docking
ivermectin
molecular modeling
SARS-CoV-2
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