Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians

Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians

The top genetic association signal for type 2 diabetes (T2D) in Southwestern American Indians maps to intron 15 of KCNQ1, an imprinted gene. We aim to understand the biology whereby variation at this locus affects T2D specifically in this genomic background. To do so, we obtained human induced pluri...

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Bibliographic Details
Main Authors: Baier, L.J (Author), Bogardus, C. (Author), Grellinger, E.D (Author), Muller, Y.L (Author), Nair, A.K (Author), Nelson, R.G (Author), Saporito, L. (Author), Sutherland, J.R (Author), Traurig, M. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
allele-specific guide RNA
CDKN1C
H19
hiPSCs
KCNQ1
pancreatic-beta like cells
type 2 diabetes
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