Skin Cancer-Associated S. aureus Strains Can Induce DNA Damage in Human Keratinocytes by Downregulating DNA Repair and Promoting Oxidative Stress

Skin Cancer-Associated S. aureus Strains Can Induce DNA Damage in Human Keratinocytes by Downregulating DNA Repair and Promoting Oxidative Stress

Actinic keratosis (AK) is a premalignant lesion, common on severely photodamaged skin, that can progress over time to cutaneous squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC, but it is unknown whether this has a direct impact on skin canc...

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Bibliographic Details
Main Authors: Frazer, I.H (Author), Hill, M.M (Author), Hugenholtz, P. (Author), Kolka, C.M (Author), Krueger, A. (Author), Linedale, R. (Author), Mohamed, A. (Author), Morrison, M. (Author), Soyer, H.P (Author), Stoll, T. (Author), Zaugg, J. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
actinic keratosis
cancer-promoting toxins
DNA repair
genotoxicity
keratinocytes
oxidative stress
phenol soluble modulins
proteomics
squamous cell carcinoma
Staphylococcus aureus
transcriptomics
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