Glycolysis Dependency as a Hallmark of SF3B1-Mutated Cells

Glycolysis Dependency as a Hallmark of SF3B1-Mutated Cells

SF3B1 mutations are recurrent in cancer and result in aberrant splicing of a previously defined set of genes. Here, we investigated the fate of aberrant transcripts induced by mutant SF3B1 and the related functional consequences. We first demonstrate that mutant SF3B1 does not alter global nascent p...

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Main Authors: Alsafadi, S. (Author), Canbezdi, C. (Author), Dayot, S. (Author), Gentric, G. (Author), Guyonnet, L. (Author), Houy, A. (Author), Loew, D. (Author), Lombard, B. (Author), Martineau, S. (Author), Mieulet, V. (Author), Nemati, F. (Author), Richon, S. (Author), Roman-Roman, S. (Author), Servois, V. (Author), Silva, L. (Author), Stern, M.-H (Author), Tarin, M. (Author), Vagner, S. (Author), Vivet-Noguer, R. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
glycolysis
metabolism
SF3B1
splicing
uveal melanoma
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