Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma

Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma

Despite the addition of several new agents to the armamentarium for the treatment of multiple myeloma (MM) in the last decade and improvements in outcomes, the refractory and relapsing disease continues to take a great toll, limiting overall survival. Therefore, additional novel approaches are neede...

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Main Authors: Al-Janadi, A. (Author), Alkharabsheh, O. (Author), Bailie, M. (Author), Bernard, J.J (Author), Bernard, M.P (Author), Ellsworth, E. (Author), Giletto, M.B (Author), Harris, C.M (Author), Isaac, D. (Author), Lansdell, T.A (Author), Lau, S. (Author), Njomen, E. (Author), Schall, P.Z (Author), Tang, T. (Author), Taylor, C. (Author), Tepe, J.J (Author), Vanecek, A. (Author), Yang, Y.-T (Author), Yuzbasiyan-Gurkan, V. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
chemotherapy
multiple myeloma
MYC
novel treatment
protein degradation
proteosome
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