Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without effective late-stage treatment, since N-acetyl cysteine must be administered...

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Main Authors: Andrade, R.J (Author), Bizkarguenaga, M. (Author), Bravo, M. (Author), Carracedo, A. (Author), Castell, J.V (Author), Cubero, F.J (Author), Delgado, T.C (Author), Falcon-Perez, J.M (Author), Fernández-Ramos, D. (Author), Fernández-Tussy, P. (Author), Gil-Pitarch, C. (Author), Goikoetxea-Usandizaga, N. (Author), González-Recio, I. (Author), Jover, R. (Author), Lachiondo-Ortega, S. (Author), Lopitz-Otsoa, F. (Author), Lucena, M.I (Author), Mabe, J. (Author), Martínez-Chantar, M.L (Author), Martínez-Cruz, L.A (Author), Mercado-Gómez, M. (Author), Morán, L. (Author), Petrov, P. (Author), Rodríguez-Agudo, R. (Author), Serrano-Maciá, M. (Author), Simón, J. (Author), Van Liempd, S.M (Author), Zabala-Letona, A. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
acetaminophen (APAP)
ammonia
drug-induced liver injury (DILI)
methionine cycle
miR-873-5p
mitochondria
polyamines
therapy
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