Multi-Omics Integration Highlights the Role of Ubiquitination in CCl₄-Induced Liver Fibrosis

by Maria Mercado-Gómez, Fernando Lopitz-Otsoa, Mikel Azkargorta, Marina Serrano-Maciá, Sofia Lachiondo-Ortega, Naroa Goikoetxea-Usandizaga, Rubén Rodríguez-Agudo, David Fernández-Ramos, Maider Bizkarguenaga, Virginia Gutiérrez-de Juan, Benoît Lectez, Kerman Aloria, Jesus M. Arizmendi, Jorge Simon, Cristina Alonso, Juan J. Lozano, Matias A. Avila, Jesus M. Banales, Jose J. G. Marin, Naiara Beraza, José M. Mato, Félix Elortza, Rosa Barrio, James D. Sutherland, Ugo Mayor, María L. Martínez-Chantar, Teresa C. Delgado
Published 2020-11-01

Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury

by Paula Iruzubieta, Naroa Goikoetxea-Usandizaga, Lucía Barbier-Torres, Marina Serrano-Maciá, David Fernández-Ramos, Pablo Fernández-Tussy, Virginia Gutiérrez-de-Juan, Sofia Lachiondo-Ortega, Jorge Simon, Miren Bravo, Fernando Lopitz-Otsoa, Mercedes Robles, Carlos Ferre-Aracil, Marta Varela-Rey, Natalia Elguezabal, José Luis Calleja, Shelly C. Lu, Malgorzata Milkiewicz, Piotr Milkiewicz, Juan Anguita, María J. Monte, José J.G. Marin, Marcos López-Hoyos, Teresa C. Delgado, Mercedes Rincón, Javier Crespo, María Luz Martínez-Chantar
Published 2021-06-01

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

by Lucía Barbier-Torres, Paula Iruzubieta, David Fernández-Ramos, Teresa C. Delgado, Daniel Taibo, Virginia Guitiérrez-de-Juan, Marta Varela-Rey, Mikel Azkargorta, Nicolas Navasa, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Jorge Simon, Fernando Lopitz-Otsoa, Sofia Lachiondo-Ortega, Javier Crespo, Steven Masson, Misti Vanette McCain, Erica Villa, Helen Reeves, Felix Elortza, Maria Isabel Lucena, Maria Isabel Hernández-Alvarez, Antonio Zorzano, Raúl J. Andrade, Shelly C. Lu, José M. Mato, Juan Anguita, Mercedes Rincón, María Luz Martínez-Chantar
Published 2017-12-01

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

by Marina Serrano-Maciá, Jorge Simón, Maria J. González-Rellan, Mikel Azkargorta, Naroa Goikoetxea-Usandizaga, Fernando Lopitz-Otsoa, Diego Saenz De Urturi, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, Maria Mercado-Gomez, Virginia Gutiérrez de Juan, Maider Bizkarguenaga, David Fernández-Ramos, Xabier Buque, Guido A. Baselli, Luca V.C. Valenti, Paula Iruzubieta, Javier Crespo, Erica Villa, Jesus M. Banales, Matias A. Avila, Jose J.G. Marin, Patricia Aspichueta, James Sutherland, Rosa Barrio, Ugo Mayor, Félix Elortza, Dimitris P. Xirodimas, Rubén Nogueiras, Teresa C. Delgado, María Luz Martínez-Chantar
Published 2021-11-01

Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity

by Pablo Fernández-Tussy, Rubén Rodríguez-Agudo, David Fernández-Ramos, Lucía Barbier-Torres, Imanol Zubiete-Franco, Sergio López de Davalillo, Elisa Herraez, Naroa Goikoetxea-Usandizaga, Sofia Lachiondo-Ortega, Jorge Simón, Fernando Lopitz-Otsoa, Virginia Gutiérrez-de Juan, Misti V. McCain, Maria J. Perugorria, Jon Mabe, Nicolás Navasa, Cecilia M. P. Rodrigues, Isabel Fabregat, Loreto Boix, Victor Sapena, Juan Anguita, Shelly C. Lu, José M. Mato, Jesus M. Banales, Erica Villa, Helen L. Reeves, Jordi Bruix, Maria Reig, Jose J. G. Marin, Teresa C. Delgado, María L. Martínez-Chantar
Published 2021-05-01