Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens

Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens

Opioid addiction remains a widespread issue despite continuous attempts by the FDA to help maintain abstinence. Melatonin is a neurohormone considered to be involved only in the neuroendocrine and reproductive systems; however, recent reports have demonstrated its potential to attenuate drug addicti...

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Bibliographic Details
Main Authors: Alghamdi, B.S (Author), Alshehri, F.S (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
addiction
animal experiment
animal model
animal tissue
antiinflammatory activity
Article
BDNF
brain derived neurotrophic factor
brain region
conditioned place preference test
controlled study
CREB
cyclic AMP responsive element binding protein
GLT-1
immunoglobulin enhancer binding protein
male
melatonin
messenger RNA
mobilization
morphine
morphine addiction
mRNA expression level
nervous system inflammation
neurotrophin
NF-κB
nonhuman
nucleus accumbens
place preference
protein expression
rat
rest
total distance traveled
vesicular glutamate transporter 1
Wistar rat
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