Glutamatergic Neurotransmission Controls the Functional Lateralization of the mPFC in the Modulation of Anxiety Induced by Social Defeat Stress in Male Mice

Glutamatergic Neurotransmission Controls the Functional Lateralization of the mPFC in the Modulation of Anxiety Induced by Social Defeat Stress in Male Mice

The rodent medial prefrontal cortex (mPFC) is anatomically divided into cingulate (Cg1), prelimbic (PrL), and infralimbic (IL) subareas. The left and right mPFC (L and RmPFC) process emotional responses induced by stress-related stimuli, and LmPFC and RmPFC inhibition elicit anxiogenesis and anxioly...

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Bibliographic Details
Main Authors: Baptista-de-Souza, D. (Author), Canto-de-Souza, L. (Author), Fresca da Costa, V. (Author), Nunes-de-Souza, R.L (Author), Santos-Costa, N. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
animal experiment
animal model
animal tissue
anxiety
anxiety disorder
Article
calcium calmodulin dependent protein kinase II
CaMKII
chronic social defeat
chronic social defeat stress
cingulate gyrus
controlled study
elevated plus maze test
emotionality
glutamatergic neurotransmission
glutamatergic transmission
hemispheric dominance
infralimbic cortex
left hemisphere
male
medial prefrontal cortex
mice
mouse
mPFC
nerve projection
nonhuman
prelimbic cortex
right hemisphere
social avoidance behavior
social interaction
transcription factor delta FosB
ΔFosB
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