Evaluation of a series of 9,10-anthraquinones as antiplasmodial agents

Background: A phytochemical study on medicinal plants used for the treatment of fever and malaria in Africa yielded metabolites with potential antiplasmodial activity, many of which are Anthraquinones (AQ). AQs have similar sub-structure as naphthoquinones and xanthones, which were previously report...

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Main Authors:	Choo, C.Y (Author), Ideris, S. (Author), Imran, S. (Author), Ismail, N.H (Author), Osman, C.P (Author), Tumewu, L. (Author), Widyawaruyanti, A. (Author)
Format:	Article
Language:	English
Published:	Bentham Science Publishers B.V. 2019
Subjects:	1 hydroxy 2 methoxy 9,10 anthraquinone 1 hydroxy 2 methyl 9,10 anthraquinone 1 hydroxy 2,6 dimethyl 9,10 anthraquinone 1 hydroxy 3 methoxy 9,10 anthraquinone 1 hydroxy 3 methyl 9,10 anthraquinone 1 hydroxy 3,6 dimethyl 9,10 anthraquinone 1 hydroxy 4 methoxy 9,10 anthraquinone 1 hydroxy 4 methyl 9,10 anthraquinone 1 hydroxy 4,6 dimethyl 9,10 anthraquinone 1 methoxy 2,6 dimethyl 9,10 anthraquinone 1 methoxy 3 methyl 9,10 anthraquinone 1 methoxy 3,6 dimethyl 9,10 anthraquinone 1 methoxy 4 methyl 9,10 anthraquinone 1,2 dihydroxy 9,10 anthraquinone 1,2 dimethoxy 9,10 anthraquinone 1,3 dihydroxy 6 methyl 9,10 anthraquinone 1,3 dihydroxy 6 methylanthraquinone 1,3 dihydroxy 9,10 anthraquinone 1,3 dimethoxy 9,10 anthraquinone 1,4 dimethoxy 9,10 anthraquinone 2 hydroxy 3,6 dimethyl 9,10 anthraquinone 3 hydroxy 2 methyl 9,10 anthraquinone Anthraquinone anthraquinone derivative antimalarial agent Antiplasmodial antiplasmodial activity Beta-hematin carbon nuclear magnetic resonance carbonyl derivative dimerization Friedel Crafts reaction hematin HRP2 hydrogen bond IC50 in vitro study Letter lipid liver cell Malaria methyl group molecular docking nonhuman Plasmodium falciparum priority journal proton nuclear magnetic resonance quinizarin Synthesis unclassified drug unindexed drug
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Evaluation of a series of 9,10-anthraquinones as antiplasmodial agents

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